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Extend half-life beyond the standard.

With Esperoct®, factor VIII levels stay high—longer.a

aCompared with standard half-life products.

Extend half-life beyond the standard.

With Esperoct®, factor VIII levels stay high—longer.a

aCompared with standard half-life products.

Extended half-life (EHL) vs standard half-life (SHL).

The Esperoct® EHL formula ensures that factor stays in your body longer—in fact, 60% longer than SHL products in adults and up to 85% longer in children.b,c

In adults.

Esperoct® half-life in clinical study
Esperoct® half-life in clinical study
Esperoct® half-life in clinical study
Esperoct® half-life in clinical study

In children <12 years old.

Child's Cape

bData shown are from a comparison study of 26 previously treated patients (PTPs) 18 years or older who received a 25, 50, or 75 IU/kg dose of their previous SHL product followed by the same dose of Esperoct®. To allow for comparison, all results were adjusted to a 50 IU/kg dose of each product.
cComparison to prior FVIII product was performed at the beginning of the study in previously treated children. Esperoct® half-life was 14.7 hours in 12 children ages 0–5 and 13.8 hours in 10 children 6–11.
dData shown are from 42 adults who received a pharmacokinetic (PK) assessment around the first Esperoct® 50 IU/kg dose.
eComparison to prior FVIII product was performed at the beginning of the study in previously treated children. The geometric mean terminal half-life in 23 children aged 0-<12 years was 14.3 hours. Esperoct® geometric mean terminal half-life was 14.7 hours in 12 children ages 0–5 and 13.8 hours in 10 children ages 6-11.

Half-life image

What is half-life?

Half-life is the time it takes for the level of factor in the blood to fall by half.

Half-life image

What is half-life?

Half-life is the time it takes for the level of factor in the blood to fall by half.

What is the difference between standard half-life factor VIII and Esperoct®?

Esperoct® is made by taking the existing factor VIII molecule and adding PEGylation technology to extend the product’s half-life.

A switch from standard half-life treatment—to Esperoct® means factor levels remain high from one dose to the next.

Hemophilia A Resources
Hemophilia A Resources

PEGylation explained.

When polyethylene glycol chains—or PEG—attach to a drug’s molecule, the process is called PEGylation. The effect of PEGylation is to extend the useful half–life of the product.

Start with the factor VIII molecule

Standard half-life factor VIII molecules are made up of various elements, including proteins and polypeptides.

Esperoct® drug molecule - PEGylation
Esperoct® drug molecule - PEGylation

Add the PEG technology

Attaching a PEG molecule to the factor VIII polypeptide extends the time it takes the body to clear the factor. We call the resulting extended half-life factor Esperoct®.

Fewer infusions a year.

If your factor VIII product lasts longer—like Esperoct® does—you won’t need to infuse as often, saving time in your busy schedule. Ready to learn about beginning treatment?

Hemophilia Community Liaisons

More questions about EHL?

You have a great resource in your regional Hemophilia Community Liaison (HCL), who can answer questions about extended half-life, PEGylation, and anything else Esperoct® related.

Esperoct® email newsletter

Support for your life with hemophilia.

Living with hemophilia is about more than treatment. Sign up for our emails to receive bleeding disorder tips and community resources—as well as product updates and information.

Esperoct® FAQs
Esperoct® FAQs

Your questions, answered.

Question: Why is knowing a product’s half-life important?

Answer: Measuring a factor’s half-life gives doctors, patients and caregivers the opportunity to compare the factor activity level of different products by calculating the time it takes the body to metabolize or inactivate half the amount of factor.

How long factor stays in the blood, however, is only half the battle. The other consideration is the factor level. The extended half-life of Esperoct® offers high factor levels for longer.a

Question: Is PEGylation a new process?

Answer: PEGylation is actually a well-established technology that has been used for years to treat other conditions.

Selected Important Safety Information

Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face

What is Esperoct®?

Esperoct® [antihemophilic factor (recombinant), glycopegylated-exei] is an injectable medicine to treat and prevent or reduce the number of bleeding episodes in people with hemophilia A. Your healthcare provider may give you Esperoct® when you have surgery

  • Esperoct® is not used to treat von Willebrand Disease

Important Safety Information

Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face
What should I tell my healthcare provider before using Esperoct®?
  • Before taking Esperoct®, you should tell your healthcare provider if you have or have had any medical conditions, take any medicines (including non-prescription medicines and dietary supplements), are nursing, pregnant or planning to become pregnant, or have been told that you have inhibitors to factor VIII
  • Your body can make antibodies called “inhibitors” against Esperoct®, which may stop Esperoct® from working properly. Call your healthcare provider right away if your bleeding does not stop after taking Esperoct®
What are the possible side effects of Esperoct®?
  • Common side effects of Esperoct® include rash or itching, and swelling, pain, rash or redness at the location of infusion

Please click here for Prescribing Information.

Esperoct® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.