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Stay protected from bleeds.

Esperoct® is made with your treatment needs in mind.

Adult walking outside

As a prophylaxis: Dose less oftena without sacrificing protection.

Routine prophylaxis with Esperoct® reduces the frequency of bleeding episodes.  

aCompared to SHL products, 50% fewer infusions when administered every other day and 40% fewer when administered 3x weekly.

b175 PTPs with severe hemophilia A received Esperoct® 50 IU/kg every 4 days for 76 weeks based on median annualized bleed rates shown.

cData shown are from a study of 68 previously treated children (34 aged 0–5 and 34 aged 6–11) who received an average dose of approximately 65 IU/kg twice weekly for 26 weeks. Median annualized bleeding rates are shown.


On-demand: The bleed control you count on.

The effectiveness of Esperoct® for on-demand treatment and control of hemophilia A was shown in a study of adults and adolescents.

Esperoct® bleed control statistic
Esperoct® bleed control statistic

of bleeds controlled with 1-2 infusionsd

Esperoct® vial
Esperoct® vial

dData shown are from a study where 12 adult and adolescent PTPs with severe hemophilia chose to be treated on demand and received Esperoct® for 532 bleeding episodes.


In surgery: Esperoct® is there when you need it.

From tooth extraction to joint replacement, count on extended half-life Esperoct® to help control the bleeding.

Tested in 45 major surgical procedures for effectiveness at controlling bleeding.

Of those 45 surgeries, 15 were joint replacements and 9 were arthroscopic procedures.

Doctors rated Esperoct® “excellent” or “good” at stopping bleeding during surgery 95.6% of the time.e

eBased on a 4.0 scale of excellent, good, moderate and none.

Esperoct® safety profile
Esperoct® safety profile

Safety in mind.

Investigate the safety facts behind Esperoct®, tested in the largest and longest clinical trial ever conducted in the field of hemophilia A.

Hemophilia Community Liaisons - Brunette female
Hemophilia Community Liaisons - Brunette female

HCL Connect.

Questions about switching to Esperoct®? Connect with your Hemophilia Community Liaison (HCL) and get personalized support during the process. Find your HCL now.

Esperoct® FAQs
Esperoct® FAQs

Your questions, answered.

Question: How is it possible to dose less often while maintaining higher factor levels?

Answer: Esperoct® is an extended half-life (EHL) factor. In a study of adults and adolescents treated with Esperoct® for prophylaxis, researchers confirmed that the recombinant stays in the body longer than standard half-life products.f And that typically means dosing less often. This EHL, in combination with the ability of Esperoct® to keep factor levels in adults at or above 3% for 100% of the timeg, leads to effective bleed protection. 

Question: How is Esperoct® used for surgery?

Answer: The number of doses and length of treatment varies by both procedure and patient. Your hematologist and surgeon will work together to create the best treatment plan for your circumstances.

fData shown are from a comparison study of 26 previously treated patients (PTPs) 18 years or older who received a 25, 50, or 75 IU/kg dose of their previous SHL product followed by the same dose of Esperoct®. To allow for comparison, all results were adjusted to a 50 IU/kg dose of each product.

gData shown are from a study where 175 previously treated adolescents and adults received routine prophylaxis with Esperoct 50 IU/kg every 4 days for 76 weeks. Pre-dose factor activity (trough) levels were evaluated at follow-up visits. Mean trough levels for adolescents (12-<18 years) were 2.7 IU/dL.

Selected Important Safety Information

Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face

What is Esperoct®?

Esperoct® [antihemophilic factor (recombinant), glycopegylated-exei] is an injectable medicine to treat and prevent or reduce the number of bleeding episodes in people with hemophilia A. Your healthcare provider may give you Esperoct® when you have surgery

  • Esperoct® is not used to treat von Willebrand Disease

Important Safety Information

Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face
What should I tell my healthcare provider before using Esperoct®?
  • Before taking Esperoct®, you should tell your healthcare provider if you have or have had any medical conditions, take any medicines (including non-prescription medicines and dietary supplements), are nursing, pregnant or planning to become pregnant, or have been told that you have inhibitors to factor VIII
  • Your body can make antibodies called “inhibitors” against Esperoct®, which may stop Esperoct® from working properly. Call your healthcare provider right away if your bleeding does not stop after taking Esperoct®
What are the possible side effects of Esperoct®?
  • Common side effects of Esperoct® include rash or itching, and swelling, pain, rash or redness at the location of infusion

Please click here for Prescribing Information.

Esperoct® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.